F-actin (green) and nuclear (blue) staining reveals the morphology of the wound edge.
Dye that labels reactive oxygen species (ROS) highlights the new tissues of the blastema in green/red.
Synapsin labeling (green) of the planarian anterior nervous system and brain.
F-actin (green) and nuclear (blue) staining reveals the morphology of the wound edge.
Publications
(** graduate student, * undergraduate student)
Hack SJ**, Beane WS, Tseng K-AS. (2023) Biophysics at the edge of life and death: Radical control of apoptotic mechanisms. Front in Cell Death. Sec. Apoptosis (2) doi 10.3389/fceld.2023.1147605. View PDF
Kinsey LJ**, Van Huizen AV**, Beane WS. (2023) Weak magnetic fields modulate superoxide to control planarian regeneration. Front in Physics. Section: Biophysics. 04 January 2023. Vol.10 – 2022. DOI: 10.3389/fphy.2022.1086809. View PDF
Hack SJ**, Kinsey LJ**, Beane WS. (2021) An Open Question: Is Non-Ionizing Radiation a Tool for Controlling Apoptosis-Induced Proliferation? Int. J. Mol. Sci. 2021 Oct 16;22(20):11159. View PDF
Beane WS, Adams DS, Morokuma J, Levin M. (2019) Live imaging of intracellular pH in planarians using the ratiometric fluorescent dye SNARF-5F-AM. Biol Methods Protoc. 2019;4(1):bpz005. View PDF
Van Huizen AV**, Morton JM*, Kinsey LJ**, Von Kannon DG**, Saad MA*, Birkholz TR**, Czajka JM*, Cyrus J, Barnes FS, Beane WS. (2019) Weak magnetic fields alter stem cell–mediatedgrowth. Science Advances 5, eaau7201. View PDF
Birkholz TR**, Van Huizen AV**, Beane WS. (2019) Staying in Shape: Planarians as a Model for Understanding Regenerative Morphology. Semin Cell Dev Biol. Mar;87:105-115. View PDF
Van Huizen AV**, Tseng AS, Beane WS. (2017) Methylisothiazolinone Toxicity and Inhibition of Wound Healing and Regeneration in Planaria. Aquat Toxicol. Oct;191:226-235. View PDF
Birkholz TR**, Beane WS. (2017) The Planarian TRPA1 Homolog Mediates Extraocular Behavioral Responses to Near Ultraviolet Light. J Exp Biol. Jul 15;220(Pt 14):2616-2625. View PDF
Morton JM*, Saad MA*, Beane WS. (2017) Surgical Ablation Assay for Studying Eye Regeneration in Planarians. J Vis Exp. Apr 14;(122). View PDF View Video
Deochand ME**, Birkholz TR**, Beane WS. (2016) Temporal regulation of planarian eye regeneration. Regeneration (Oxf). Oct 28;3(4):209-221. View PDF
Cover: Biology Open. Vol 5(9), Sept 2016.
Cover: Regeneration (Oxf). Vol 3(2), Apr 2016
Schatzberg D, Lawton M, Hadyniak SE, Ross EJ, Carney T, Beane WS, Levin M, Bradham CA. (2015) H+/K+ ATPase activity is required for biomineralization in sea urchin embryos. Dev Biol. Oct 15;406(2):259-70. View PDF
Paskin TR**, Jellies J, Bacher J*, Beane WS. (2014) Planarian phototactic assay reveals differential behavioral responses based on wavelength. PLoS One. Dec 10;9(12):e114708. View PDF
Beane WS, Morokuma J, Lemire J, Levin M. (2013) Bioelectric signaling regulates head and organ size during planarian regeneration. Development. Jan;140(2):313-322. View PDF
Beane WS, Tseng A, Morokuma J, Lemire J, Levin M. (2012) Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis and development. Stem Cells Dev. Aug 10;21(12):2085-94. View PDF [Cover Image]
Lobo D, Beane WS, Levin M. (2012) Modeling planarian regeneration: a primer for reverse-engineering the worm. PLoS Comput Biol. 8(4) e1002481. View PDF [Featured Image]
Beane WS, Morokuma J, Adams DS, Levin M. (2011) A chemical genetics approach revels H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem Biol (Cell Press). Jan 28;18(1):77-89. View PDF
Tseng AS, Beane WS, Lemire JM, Masi A, Levin M (2010). Induction of vertebrate regeneration by a transient sodium current. J Neurosci. Sep 29;30(39):13192-200. View PDF [Cover Image]
Stevenson CG and Beane WS (2010) A low percent ethanol method for immobilizing planarians. PLoS One. Dec 14;5(12):e15310. View PDF
Oviedo NJ and Beane WS (2009). Regeneration: The origin of cancer or a possible cure? Semin Cell Dev Biol. Jul;20(5):557-64. View PDF
Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere A-M, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lapage T, Gache C, McClay DR, Manning G (2006). The sea urchin kinome: a first look. Dev Biol. Dec 1; 300(1):180-193.
Morales J, Mulner-Lorillon O, Cosson B, Morin E, Bellé R, Bradham CA, Beane WS, Cormier P (2006). Translational control genes in the sea urchin genome. Dev Biol. Dec 1; 300(1):293-307.
Beane WS, Voronina E, Wessel GM, McClay DR (2006). Lineage-specific expansions provide genomic complexity among sea urchin GTPases. Dev Biol. Dec 1; 300(1):165-179.
The Sea Urchin Genome Sequencing Consortium (2006). The genome of the sea urchin Strongylocentrotus purpuratus. Science. Nov 10;314(5801):941-952. (My data Fig. 4.)
Beane WS, Gross JM, McClay DR. (2006) RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation. Dev Biol. Apr 1; 292(1):213-25.